CRYSTALS OF ACID SALTS AND ACID SALTS OF DAPOXETINE AND PREPARATION METHODS THEREFOR

摘要

Disclosed are crystals of acid salts and the acid salts of dapoxetine and preparation methods therefor. The crystals are crystals of methanesulfonate, nitrate, and hydrobromide of dapoxetine, and crystals of gentisate, orotate, cyclamate, acetyl salicylate, hippurate, or 1,5-naphthalene sulfonate. The acid salts of dapoxetine are gentisate, orotate, acetyl salicylate, hippurate, or 1,5-naphthalene sulfonate of dapoxetine. The aqueous solubility of the several salts and crystals of dapoxetine of the present invention are all significantly greater than the solubility of dapoxitine free base, and have improved stability and hygroscopicity.