Enhanced cytotoxicity of anti-CD74 and anti-HLA-DR antibodies with interferon-gamma
摘要
Disclosed herein are methods and compositions comprising interferon-γ(IFN-γ) and anti-CD74 or anti-HLA-DR antibodies. In preferred embodiments, the IFN-γincreases the expression of CD74 and/or HLA-DR in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD74 or anti-HLA-DR antibodies. The compositions and methods are of use to treat diseases involving CD74
申请公布号
AU2011203890(B2)
申请公布日期
2013.05.30
申请号
AU20110203890
申请日期
2011.01.11
申请人
CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY;IMMUNOMEDICS, INC.