CO-SOLVENT COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF DANTROLENE THERAPEUTIC AGENTS
摘要
<p>The present invention provides for methods of using terf-butyl alcohol (TBA) co-solvent systems in the formulation and production of a pharmaceutical agent with low solubility. The present invention also provides for pharmaceutical compositions made using the novel co-solvent system. In one embodiment, the invention provides for a method of making dantrolene sodium (DS) formulation for intravenous use (DS-IV). This instantaneous reconstitution of the DS-IV product constitutes a significant improvement in the pharmacotherapy of patients undergoing malignant hyperthermia during surgery.</p>
申请公布号
WO2009048698(A4)
申请公布日期
2013.05.30
申请号
WO2008US75406
申请日期
2008.09.05
申请人
US WORLDMEDS LLC;MALKAWI, AHMAD;AL-GHANANEEM, ABEER, M.;DELUCA, PATRICK;DIGENIS, GEORGE, A.
发明人
MALKAWI, AHMAD;AL-GHANANEEM, ABEER, M.;DELUCA, PATRICK;DIGENIS, GEORGE, A.