| 摘要 |
C/NRPonbDCC/KXM/X 345979_DI OC-I6/0D/2IIi Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of local hypothermia of the brain region for 5 neuroprotection. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. Various disposable heat exchange cassettes are attached to the circulatory flow lines of the catheter, the heat exchange cassettes being sized to engage cavities within various re-usable control units. The control units include a heater/cooler device, a 10 user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up and down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages 15 with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the .desired target temperature. WO 02/07793 PCT[USOI/23009 C~ cn o Do Is C') Cc W Cv < a:: 0 z 2w r.j CvJC cc LW UL 0 |
