发明名称 |
N-BIPHENYLMETHYLBENZIMIDAZOLE MODULATORS OF PPARG |
摘要 |
<p>The invention provides molecular entities that bind with high affinity to PPARG (PPAR?), inhibit cdk5-mediated phosphorylation of PPARG, but do not exert an agonistic effect on PPARG. Compounds of the invention can be used for treatment of conditions in patients wherein PPARG plays a role, such as diabetes or obesity. Methods of preparation of the compounds, bioassay methods for evaluating compounds of the invention as non-agonistic PPARG binding compounds, and pharmaceutical compositions are also provided.</p> |
申请公布号 |
WO2013078240(A1) |
申请公布日期 |
2013.05.30 |
申请号 |
WO2012US66135 |
申请日期 |
2012.11.20 |
申请人 |
RIPKA, AMY S.;SAUNDERS, JEFFREY O. |
发明人 |
RIPKA, AMY S.;SAUNDERS, JEFFREY O.;KAMENECKA, THEODORE MARK;GRIFFIN, PATRICK R. |
分类号 |
A01N43/40 |
主分类号 |
A01N43/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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