PHARMACEUTICAL COMPOSITION CONTAINING ANTI-KIAA1114 ANTIBODY AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER INDUCED BY KIAA1114 OVER-EXPRESSION

摘要

The present invention relates to a pharmaceutical composition containing an anti-KIAA1114 antibody as an active ingredient for the prevention or treatment of cancer induced by KIAA1114 over-expression. The anti-KIAA1114 antibody of the present invention specifically binds to an extracellular domain of a KIAA1114 protein, specifically reacts with various cancer cell lines and remarkably represses metastasis of cancer in vivo in a lung metastasis animal model using a KIAA1114 over-expression cancer cell line. Therefore, the anti-KIAA1114 antibody of the present invention can be effectively used for the prevention or treatment of cancer - particularly metastatic cancer, which is caused by KIAA1114 over-expression.