发明名称 |
TOPICAL TREATMENT OF NEUROPATHIC PAIN AND METHODS OF DIAGNOSIS |
摘要 |
Alpha-2 adrenergic agonists such as clonidine may be used to treat the pain associated with painful diabetic neuropathy (PDN) only in a subset of these patients. Targeted nociceptors (pain fibers) must be functionally expressed in the skin in order for clonidine to have a therapeutic effect. Neuropathies associated with pain differ with respect to the expression of nociceptors in the skin. Clonidine targets alpha-2 adrenergic receptors on the terminals of nociceptors. The presence of the targeted nociceptors may be determined by topical application of a TRPV1 agonist such as capsaicin. Patients who detect the capsaicin as a pain stimulus applied near the painful area have expression in the skin of the requisite targeted nociceptors and the targeted alpha-2 adrenergic receptors. The test is referred to as a capsaicin challenge test. This test significantly improves clinical outcomes in topical neuropathic pain treatment. |
申请公布号 |
EP2595617(A1) |
申请公布日期 |
2013.05.29 |
申请号 |
EP20110761177 |
申请日期 |
2011.07.18 |
申请人 |
ARCION THERAPEUTICS, INC. |
发明人 |
CAMPBELL, JAMES, N. |
分类号 |
A61K31/165;A61K9/00;A61K9/08;A61K31/357;A61K31/4168;A61K47/32;A61M35/00;A61P25/02 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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