发明名称 |
SEQUENCE SPECIFIC DOUBLE-STRANDED DNA/RNA BINDING COMPOUNDS AND USES THEREOF |
摘要 |
<p>The present invention provides specific double-stranded DNA/RNA binding compounds having a polymeric structure, which are in fact, triplex forming molecules capable of binding tightly and specifically to predetermined sequences in the major groove of double stranded nucleic acid molecules; as well as pharmaceutical compositions comprising thereof. The triplex forming molecules and the pharmaceutical compositions of the invention can be used for various therapeutic applications such as site-specific modulation of gene expression and targeting of DNA or RNA damage, as well as for diagnostic applications in vitro.</p> |
申请公布号 |
EP2596102(A2) |
申请公布日期 |
2013.05.29 |
申请号 |
EP20110751950 |
申请日期 |
2011.07.21 |
申请人 |
GENEARREST LTD |
发明人 |
RAYAN, ANWAR;FALAH, MIZIED |
分类号 |
C12N15/113;C07H19/16;C07K14/00 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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