发明名称 |
MUTEINS OF THE PYRROLINE-5-CARBOXYLATE REDUCTASE 1 |
摘要 |
<p>The invention relates to muteins of the pyrroline-5-carboxylate reductase 1 (PYCR1), to nucleic acid molecules comprising a nucleotide sequence encoding such muteins, to methods of determining in a subject a predisposition of having an age related disorder associated with PYCR1, to methods of identifying a compound capable of modifying the expression of PYCR1 and methods of treating a subject having an age-related disorder associated with PYCR1. The invention further relates to a genetically modified animal and a method of modifying the expression of the PYCR1 gene in an animal.</p> |
申请公布号 |
EP2435470(A4) |
申请公布日期 |
2013.05.29 |
申请号 |
EP20100780124 |
申请日期 |
2010.05.26 |
申请人 |
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH |
发明人 |
REVERSADE, BRUNO;MUNDLOS, STEFAN |
分类号 |
C07K14/47;A61K38/44;A61P43/00;C12N5/10;C12N9/06;C12N15/53;C12Q1/00 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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