| 发明名称 |
HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF |
| 摘要 |
The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject. |
| 申请公布号 |
EP2509590(A4) |
申请公布日期 |
2013.05.29 |
| 申请号 |
EP20100836767 |
申请日期 |
2010.12.10 |
| 申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
FENG, YEN;FA, MAURO;ARANCIO, OTTAVIO;DENG, SHIXIAN;LANDRY, DONALD, W.;FRANCIS, YITSHAK |
| 分类号 |
A61K31/27;C07C235/64;C07C311/29;C07C323/31;C07C323/62;C07D213/75;C07D213/82;C07D233/90;C07D333/38 |
主分类号 |
A61K31/27 |
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