<p>Method for preparing a practically anhydrous tiotropium bromide micronizate (A) comprises comminuting crystalline tiotropium bromide monohydrate (I) in a gas-jet mill in which the particles are comminuted in a fluidized powder bed. An independent claim is included for (A) produced by the new method. - ACTIVITY : Antiasthmatic. No details of tests for antiasthmatic activity are given. - MECHANISM OF ACTION : Anticholinergic.</p>
申请公布号
EP1962960(B1)
申请公布日期
2013.05.29
申请号
EP20060830454
申请日期
2006.12.07
申请人
BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG
发明人
RASENACK, NOBERT;WALZ, MICHAEL;GRAEBNER, HAGEN;TRUNK, MICHAEL