| 发明名称 |
ENHANCEMENT OF INTRACELLULAR DELIVERY AND TISSUE TARGETING OF DRUGS AND GENES |
| 摘要 |
A method for enhancing intracellular delivery of effector molecules is provided. The method involves modifying selected antibodies with biotin and streptavidin, conjugating these antibodies with an effector molecule, and delivering the conjugated effector to an intracellular target specifically recognized by the antibody.
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| 申请公布号 |
CA2323210(C) |
申请公布日期 |
2013.05.28 |
| 申请号 |
CA19992323210 |
申请日期 |
1999.03.10 |
| 申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
MUZYKANTOV, VLADIMIR R.;ALBELDA, STEVEN M. |
| 分类号 |
A61K39/395;G01N33/53;A61K31/7088;A61K38/43;A61K45/00;A61K47/48;A61K48/00;A61P37/02;A61P43/00;C07K16/28 |
主分类号 |
A61K39/395 |
| 代理机构 |
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