发明名称 |
High throughput screening for antimicrobial dosing regimens |
摘要 |
Provided herein are methods and computer-implemented systems for using computer simulations to predict likelihood of a cell population associated with a pathophysiological condition acquiring resistance to a therapeutic agent, to screen for therapeutic agents effective to suppress acquisition of resistance within a cell population and to treat the pathophysiological conditions associated therewith. The computer simulation comprises at least an input/out system and a mathematical model, including operably linked equations, parameter values and constant values, of growth response over a period of time of a cell population in contact with an therapeutic agent. Also provide is a method for determining a best-fit mathematical model of adaptation of a microbial population to a therapeutic agent over time and using the model to simulate microbial population behavior to a therapeutic agent.
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申请公布号 |
US8452543(B2) |
申请公布日期 |
2013.05.28 |
申请号 |
US20060992633 |
申请日期 |
2006.09.19 |
申请人 |
TAM VINCENT H.;NIKOLAOU MICHAEL;THE UNIVERSITY OF HOUSTON SYSTEM |
发明人 |
TAM VINCENT H.;NIKOLAOU MICHAEL |
分类号 |
G06F19/10;G06F19/00;G06G7/58 |
主分类号 |
G06F19/10 |
代理机构 |
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地址 |
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