| 摘要 |
PURPOSE: Carnosic acid, a derivative thereof, or a pharmaceutically acceptable salt thereof is provided to suppress c-kit activation and signal transduction in melanocytes, and to improve skin whitening. CONSTITUTION: A c-kit activity inhibitor contains carnosic acid of chemical formula 1, a derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient. The derivative is carnosic acid methyl ester or carnosic acid ethyl alcohol. The carnosic acid, a derivative thereof, or a pharmaceutically acceptable salt thereof is derived from rosemary and/or sage. The inhibitor contains 0.0001-10 wt% of the active ingredient. A composition for skin whitening contains the derivative of chemical formula 1 or a pharmaceutically acceptable salt thereof. The composition further contains one or more selected from a group consisting of a Gycyrrhiza extract, arbutin, ascorbic acid, and kojic acid.
|
