发明名称 |
Long-term storage of non-glycosylated recombinant Human G-CSF |
摘要 |
The present invention provides a method for stable long-term storage of non-glycosylated recombinant human G-CSF, wherein an aqueous acetate or glutamate buffered G-CSF composition containing non-glycosylated recombinant human G-CSF and sorbitol is cooled to a temperature of -15° C. or below to obtain a frozen G-CSF coFmposition, which frozen composition is then stored in the frozen state. The temperature of the frozen G-CSF composition is later increased to a temperature within the range of from 2° C. to 8° C. for a time selected to allow the G-CSF composition to thaw and to obtain a liquid G-CSF composition having a G-CSF content of at least 95% of the G-CSF content of the original composition.
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申请公布号 |
US8449873(B2) |
申请公布日期 |
2013.05.28 |
申请号 |
US201113166345 |
申请日期 |
2011.06.22 |
申请人 |
GRAUMANN KLAUS;LERCH HELMUT;LAUBER THOMAS;SANDOZ AG |
发明人 |
GRAUMANN KLAUS;LERCH HELMUT;LAUBER THOMAS |
分类号 |
A61K45/00;A61K38/00;C07K1/00 |
主分类号 |
A61K45/00 |
代理机构 |
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