PROTEIN MODIFIER PRODUCTION INHIBITOR

摘要

The compounds, at least in selected embodiments, are suitable as inhibitors of the formation of protein modification products capable of inhibiting vitamin B6 deficiency disease as a side effect, especially as a renal protective agent. There is provided a use, as an active ingredient, of any of free or salt-form compounds of either of the formulae: (I) or (II), wherein R1 is substituted or unsubstituted aromatic ring; and each of R2, R3 and R4 is a hydrogen atom or monovalent organic group, or alternatively R2 and R3 cooperate to form a condensed ring or R3 and R4 cooperate to represent a divalent organic group, provided that R3 and R4 are not simultaneously hydrogen atoms. (see formula I) (see formula II)