发明名称 |
Small volume in vitro analyte sensor and methods of making |
摘要 |
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
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申请公布号 |
US8449758(B2) |
申请公布日期 |
2013.05.28 |
申请号 |
US20090569351 |
申请日期 |
2009.09.29 |
申请人 |
FELDMAN BENJAMIN J.;HELLER ADAM;HELLER EPHRAIM;MAO FEI;VIVOLO JOSEPH A.;FUNDERBURK JEFFERY V.;COLMAN FREDRIC C.;KRISHNAN RAJESH;ABBOTT DIABETES CARE INC. |
发明人 |
FELDMAN BENJAMIN J.;HELLER ADAM;HELLER EPHRAIM;MAO FEI;VIVOLO JOSEPH A.;FUNDERBURK JEFFERY V.;COLMAN FREDRIC C.;KRISHNAN RAJESH |
分类号 |
G01N27/327;G01N33/483;C12Q1/00;C12Q1/26;G01N27/416;G01N27/42;G01N33/66 |
主分类号 |
G01N27/327 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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