TARGETING THE RB PATHWAY FOR THE PREVENTION OF CANCER

摘要

Method of preventing retinoblastoma in a cancer prone subject with RB pathway inhibitors. Preferred inhibitors are Cdk inbitors, E2f inhibitors, atypical protein kinase C inhibitors and Skp2 inhibitors. Also methods to determine the likelihood of a population of cells to be cancer-proneby measuring the activity levels of Cdk and E2f, aPKC and SKp2.