| 发明名称 |
HIGH AFFINITY LEPTINS AND LEPTIN ANTAGONISTS |
| 摘要 |
Leptin muteins, in particular leptin antagonists, with increased binding affinity to leptin receptor are provided. These compounds as well as pharmaceutical composition comprising them are useful for the treatment of any disorder in which a non-desirable or deleterious activity of endogenous leptin or an altered innate immune response is implicated. |
| 申请公布号 |
US2013133089(A1) |
申请公布日期 |
2013.05.23 |
| 申请号 |
US201113642669 |
申请日期 |
2011.04.17 |
| 申请人 |
GERTLER ARIEH;ELINAV ERAN;HALPERN ZAMIR;THE MEDICAL RESEARCH, INFRASTRUCTURE, AND HEALTH SERVICES FUND OF THE TEL-AVIV;YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY OF JERUSALEM |
发明人 |
GERTLER ARIEH;ELINAV ERAN;HALPERN ZAMIR |
| 分类号 |
C07K14/575;A61K38/22;A61K45/06 |
主分类号 |
C07K14/575 |
| 代理机构 |
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