| 摘要 |
<p>Provided in the present invention are an oxazole compound with the anti-coxsackie virus structure as shown in formula (I), or pharmaceutically acceptable salts and a preparation method, a pharmaceutical composition and the use thereof, wherein R is CH3 or CF3; R' and R" are H, alkyl or halogen; A is O, S; n is 1 to 9; B is substituted or unsubstituted triazolyl, substituted or unsubstituted dihydro-imidazolinyl, substituted or unsubstituted dihydro-oxazolyl, substituted or unsubstituted dihydro-thiazolyl, substituted or unsubstituted thiadiazolyl, substituted or unsubstituted oxadiazolyl, and substituted or unsubstituted pyrimidinyl. In comparison with the prior art, the oxazole compound of the present invention has an excellent anti-coxsackie virus activity, while having a lower toxicity and a higher safety level.</p> |
