发明名称 |
Process for the production of 2-[4-(3- or 2-fluorobenzyloxy)benzylamino]propanamides with high purity degree |
摘要 |
A process for obtaining therapeutically active 2-[4-(3- and 2-(flurobenzyloxy)benzylamino]propanamides, and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower than 0.03%, preferably lower than 0.01% by weight. The process is carried out by submitting the Schiff bases intermediates 2- [4 -(3- and 2-fluorobenzyloxy)benzylideneamino]propanamides to a reduction reaction with a reducing agent selected from sodium borohydride and potassium borohydride in an appropriate amount of an organic solvent selected from C |
申请公布号 |
AU2008334778(B2) |
申请公布日期 |
2013.05.23 |
申请号 |
AU20080334778 |
申请日期 |
2008.12.01 |
申请人 |
NEWRON PHARMACEUTICALS S.P.A. |
发明人 |
FARAVELLI, LAURA;CANEVOTTI, RENATO;BARBANTI, ELENA;SALVATI, PATRICIA;PONZINI, FRANCESCO |
分类号 |
C07C231/12;A61K31/165;A61P25/00;C07C237/08;C07C251/24 |
主分类号 |
C07C231/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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