发明名称 IMMUNIZATION BASE BOTULINUM TOXIN SERUM TYPE A ACTIVITY ASSAY
摘要 <P>PROBLEM TO BE SOLVED: To provide a pharmaceutical composition containing botulinum neurotoxin serum type A (BoNT/A). <P>SOLUTION: The pharmaceutical composition is decided by a process intercorrelating with a fact that there is a large amount of BoNT/A in the medicine, through a method for producing an &alpha;-SNAP-25 antibody that bonds to an epitope containing a carboxyl terminus in P<SB POS="POST">1</SB>residue from BoNT/A cleavage site cleavable binding from a SNAP-25 cutting product, a method for detecting &alpha;-SNAP-25 antibody and BoNT/A activity that bond to the epitope containing the carboxyl terminus in the P<SB POS="POST">1</SB>residue from BoNT/A cleavage site cleavable binding from the SNAP-25 cutting product, and a method for detecting &alpha;-BoNT/A neutralizing antibody. <P>COPYRIGHT: (C)2013,JPO&INPIT
申请公布号 JP2013100304(A) 申请公布日期 2013.05.23
申请号 JP20120279973 申请日期 2012.12.21
申请人 ALLERGAN INC 发明人 FERNANDEZ-SALAS ESTER;WANG JOANNE;GARAY PATTON E;WONG LINA S;HODGES D DIANNE;AOKI K ROGER
分类号 A61K38/00;A61P25/02;A61P25/04;A61P25/08;A61P27/02;C07K14/33;C07K16/12;G01N33/53;G01N33/543 主分类号 A61K38/00
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