摘要 |
The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core. |
申请人 |
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF;FREUND, BARBARA;HEEREN, JOERG;NIELSEN, PETER;CARAMBIA, ANTONELLA;HERKEL, JOHANNES;BRUNS, OLIVER;LOHSE, ANSGAR;LUETH, STEFAN;WELLER, HORST;SALMEN, SUNHILD;UNIVERSITAET HAMBURG;HEINRICH-PETTE-INSTITUT |
发明人 |
FREUND, BARBARA;HEEREN, JOERG;NIELSEN, PETER;CARAMBIA, ANTONELLA;HERKEL, JOHANNES;BRUNS, OLIVER;LOHSE, ANSGAR;LUETH, STEFAN;WELLER, HORST;SALMEN, SUNHILD |