| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a polyethylene glycol derivative which includes two PEG chains, which is bound to a diacylglycerol, which has high purity, and which enhances the stability of liposomes. <P>SOLUTION: The branched polyethylene glycol bound to the diacylglycerol is represented by formula (1). (In formula (1), R<SP POS="POST">1</SP>is 1-7C hydrocarbon group, R<SP POS="POST">2</SP>is 9-21C alkyl or alkenyl, n is an average addition mole number of polyethylene glycol chains, 10≤n≤100, and X is a linker site between the branched polyethylene glycol and the diacylglycerol, and is represented by formula (2)). (In formula (2), Y is ether bond, ester bond, urethane bond, amide bond, or carbonate bond, and each of l and m is an integer of 0 to 6). <P>COPYRIGHT: (C)2013,JPO&INPIT |
