发明名称 |
System And Method to Correct Out of Phase Errors In DNA Sequencing Data by Use of a Recursive Algorithm |
摘要 |
An embodiment of a method for correcting an error associated with phasic synchrony of sequence data generated from a population of template molecules is described that comprises the steps of detecting signals generated in response to nucleotide species introduced during a sequencing reaction; generating an observed value for the signal detected from each of the nucleotide species; defining positive incorporation values and negative incorporation values from the observed values using a carry forward value and an incomplete extension value; revising the carry forward value and the incomplete extension value using a noise value that is derived from observed values associated with the negative incorporation values; re-defining the positive incorporation values and the negative incorporation values using the revised carry forward value and the revised incomplete extension value; and repeating the steps of revising and re-defining until convergence of the positive incorporation values and the negative incorporation values
|
申请公布号 |
US2013131995(A1) |
申请公布日期 |
2013.05.23 |
申请号 |
US201213718852 |
申请日期 |
2012.12.18 |
申请人 |
454 LIFE SCIENCE CORPORATION;454 LIFE SCIENCES CORPORATION |
发明人 |
CHEN YI-JU;ANDREW WONG CHIU TAI |
分类号 |
G06F19/22 |
主分类号 |
G06F19/22 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|