发明名称 |
CAR+ T CELLS GENETICALLY MODIFIED TO ELIMINATE EXPRESSION OF T- CELL RECEPTOR AND/OR HLA |
摘要 |
<p>The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising disrupted T cell receptor and/or HLA and comprising a chimeric antigen receptor. In certain embodiments, the compositions are employed allogeneically as universal reagents for "off-the-shelf treatment of medical conditions such as cancer, autoimmunity, and infection. In particular embodiments, the T cell receptor-negative and/or HLA-negaiive T cells are generated using zinc finger nucleases, for example.</p> |
申请公布号 |
WO2013074916(A1) |
申请公布日期 |
2013.05.23 |
申请号 |
WO2012US65506 |
申请日期 |
2012.11.16 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
COOPER, LAURENCE, J. NEIL;TORIKAI, HIROKI |
分类号 |
C12N5/0783;C12N5/10;C12N15/12 |
主分类号 |
C12N5/0783 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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