发明名称 |
METHODS TO IDENTIFY COMBINATIONS OF NS5A TARGETING COMPOUNDS THAT ACT SYNERGISTICALLY TO INHIBIT HEPATITIS C VIRUS REPLICATION |
摘要 |
<p>The present invention is based on the surprising finding that pairs of HCV NS5A-targeting inhibitors can be identified which display similar resistance profiles yet, when combined, exhibit synergistic inhibition of wild type replicons and/or replicons carrying mutations conferring resistance to the HCV NS5A-targeting inhibitor. In addition, combinations of these molecules result in a higher genetic barrier to resistance, demonstrating their potential utility as novel combination therapies for treatment of HCV.</p> |
申请公布号 |
EP2593565(A2) |
申请公布日期 |
2013.05.22 |
申请号 |
EP20110807424 |
申请日期 |
2011.07.13 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
SUN, JIN-HUA;GAO, MIN;O'BOYLE II, DONALD R.;LEMM, JULIE A.;ROBERTS, SUSAN B.;BELEMA, MAKONEN;MEANWELL, NICHOLAS A. |
分类号 |
C12Q1/68;C12Q1/02;C12Q1/18;C12Q1/70;G01N33/50 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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