发明名称 |
CYSTEINE PROTEASE INHIBITORS |
摘要 |
Compounds of Formula II wherein R1a is H; and R1b is C1-C6alkyl, Carbocyclyl or Het; or R1a and R1b together define a saturated cyclic amine with 3-6 ring atoms; R2a and R2b are independently H, halo, C1-C4alkyl, C1-C4haloalkyl or C1-C4alkoxy, or R2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl; R3 is a branched C5-C10 alkyl chain, C2-C4haloalkyl or—CH2C3-C7 cycloalkyl; R4′is C1-C6alkyl, C1-C6haloalkyl or oxetany-3-yl. for use in the prophylaxis or treatment of a disorder characterized by inappropriate expression or activation of cathepsin S. |
申请公布号 |
EP2509957(A4) |
申请公布日期 |
2013.05.22 |
申请号 |
EP20100835594 |
申请日期 |
2010.12.10 |
申请人 |
MEDIVIR UK LTD |
发明人 |
AYESA, SUSANA;CARLQUIST, PETER;ERSMARK, KAROLINA;GRABOWSKA, URSZULA;HEWITT, ELLEN;JOENSSON, DANIEL;KAHNBERG, PIA;KLASSON, BJOERN;LIND, PETER;ODEN, LOURDES;PARKES, KEVIN;WIKTELIUS, DANIEL |
分类号 |
C07D231/40;A61K31/16;A61K31/415;A61K31/426;A61P9/10;A61P11/06;A61P17/06;A61P21/04;A61P37/02;A61P37/08;C07C271/22;C07D277/46;C07D405/12 |
主分类号 |
C07D231/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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