发明名称 |
MAL AND CADM1 PROMOTER METHYLATION A MOLECULAR DIAGNOSTIC MARKER FOR HPV-INDUCED INVASIVE CERVICAL CANCERS AND THEIR HIGH-GRADE PRECURSOR LESIONS |
摘要 |
<p>The inventors now have developed a (molecular) diagnostic marker based on MAL alterations, in particular reduced MAL mRNA and protein expression as well as MAL promoter hypermethylation, to identify human papillomavirus (HPV)-induced high-grade precancerous lesions such as premalignant cervical lesions of invasive cervical cancer, and high-risk human papillomavirus (HPV)-induced precursor lesions of non-cervical invasive cancers within, cell material obtained via scraping, lavage or by other means and/or tissue. In particular, the present invention relates to the use of the MAL gene (including its promoter) and the gene products thereof as marker for HPV-induced high-grade premalignant lesions, allowing early detection and better treatment option for the individual patient.</p> |
申请公布号 |
EP2283154(B1) |
申请公布日期 |
2013.05.22 |
申请号 |
EP20090732836 |
申请日期 |
2009.04.14 |
申请人 |
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG |
发明人 |
MEIJER, CHRISTOPHORUS JOANNES LAMBERTUS MARIA;SNIJDERS, PETRUS JOSEPHUS FERDINANDUS;STEENBERGEN, RENSKE DANIELA MARIA |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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