发明名称 |
Tyrosine-modified recombinant rAAV vector compositions and methods for use |
摘要 |
Disclosed are tyrosine-modified rAAV vectors, as well as infectious virions, compositions, and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and methods for using the disclosed tyrosine-phosphorylated capsid protein mutant rAAV vectors in a variety of diagnostic and therapeutic applications including in vivo and ex vivo gene therapy, and large-scale production of rAAV vectors.
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申请公布号 |
US8445267(B2) |
申请公布日期 |
2013.05.21 |
申请号 |
US20080595196 |
申请日期 |
2008.04.08 |
申请人 |
ZHONG LI;ZOLOTUKHIN SERGEI;GOVINDASAMY LAKSHMANAN;AGBANDJE-MCKENNA MAVIS;SRIVASTAVA ARUN;UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. |
发明人 |
ZHONG LI;ZOLOTUKHIN SERGEI;GOVINDASAMY LAKSHMANAN;AGBANDJE-MCKENNA MAVIS;SRIVASTAVA ARUN |
分类号 |
C12N15/00;C12N15/09 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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地址 |
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