| 摘要 |
An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid beta fibrils or monomeric amyloid beta-proteins. According to the present invention, an antibody is provided that has a higher reactivity with amylospheroids than with amyloid precursor proteins, and has any one or more of the following properties: (i) a higher activity with amylospheroids than with amyloid beta fibrils; (ii) a higher reactivity with amylospheroids than with monomeric amyloid beta-proteins; and (iii) an activity of inhibiting neuronal cell death induced by amylospheroids.
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