发明名称 |
Conjugation reactions |
摘要 |
An initiator for the terminal group of the polymer product of an atom or group radical transfer polymerisation has an activated carboxyl or an amine group which is reacted with an amine or carboxyl (respectively) group containing biologically active compound. The initiator is preferably 4-(3-(2-bromo, 2-methyl-propionate)phenyl)-propionic acid N-hydroxysuccinimide ester or 2-bromo, 2-methyl-propionic acid N-hydroxysuccinimide ester. The monomers preferably comprise a zwitterionic monomer such as 2-methacryloxyethyl-2'-trimethyl ammoniumethyl phosphate inner salt.
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申请公布号 |
US8445612(B2) |
申请公布日期 |
2013.05.21 |
申请号 |
US201113243923 |
申请日期 |
2011.09.23 |
申请人 |
LEWIS ANDREW LENNARD;LEPPARD SIMON WILLIAM;BIOCOMPATIBLES UK LIMITED |
发明人 |
LEWIS ANDREW LENNARD;LEPPARD SIMON WILLIAM |
分类号 |
C08F22/40;A61K47/48;C07C205/00;C07C229/00;C07D207/40;C07D207/46;C07F9/09;C07F9/553;C08F4/00;C08F26/06;C08F122/40;C08F126/06;C08F222/40;C08F226/06;C08F246/00;C08G63/48;C08G63/91 |
主分类号 |
C08F22/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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