发明名称 |
Bis-(alpha-amino)-diol-diester-containing poly (ester amide) and poly (ester urethane) compositions and methods of use |
摘要 |
The present invention provides biodegradable, biocompatible bis-(alpha-amino acyl)-diol-diester-containing poly(ester amide) (PEA) and poly(ester urethane) (PEUR) co-polymer compositions with mechanical properties that can be readily tailored by selection of various combinations and proportions of the building blocks of the co-polymers. The compositions are suitable for use in production of drug-releasing biodegradable particles and implantable surgical devices, such as stents and internal fixation devices. The co-polymer compositions, particles and surgical devices biodegrade in vivo by enzymatic action to release bioactive agents in a controlled manner over time as well as biocompatible breakdown products, including one to multiple different amino acids.
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申请公布号 |
US8445007(B2) |
申请公布日期 |
2013.05.21 |
申请号 |
US20060066998 |
申请日期 |
2006.09.22 |
申请人 |
GOMURASHVILI ZAZA D.;HUGHES JONATHAN MACFERRAN;DA JIE;ZHANG HUASHI;MEDIVAS, LLC |
发明人 |
GOMURASHVILI ZAZA D.;HUGHES JONATHAN MACFERRAN;DA JIE;ZHANG HUASHI |
分类号 |
A61F2/00;A01N25/08 |
主分类号 |
A61F2/00 |
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