发明名称 |
SELECTIVE PREPARATION METHOD OF (+)-CIS-SERTRALINE |
摘要 |
PURPOSE: A manufacturing method of a (+)-cis-sertaline is provided to manufacture (+)-cis-sertaline of high purity and high yield which does not includes dechlorinated sertaline byproduct, by selectively separating and purifying only a (+)-cis-sertaline. CONSTITUTION: A manufacturing method of a (±)-cis-sertaline represented by chemical formula 1 comprises: a step of manufacturing (+)-cis-sertaline (S)-(-)-2-pyrrolidone-5-carboxylate by reaction of (±)-cis/trans-sertaline represented by chemical formula 2 or (±)-cis-sertaline and (S)-(-)-2-pyrrolidone-5-carboxylate and optically dividing the product. The use amount of the (S)-(-)-2-pyrrolidone-5-carboxylate is 0.25-1.0 molar equivalent, based on 0.25-1.0 molar equivalent. The reaction solvent is selected from toluene, ethylacetate, acetone, and ethanol.
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申请公布号 |
KR20130051758(A) |
申请公布日期 |
2013.05.21 |
申请号 |
KR20110117089 |
申请日期 |
2011.11.10 |
申请人 |
BORYUNG PHARMACEUTICAL CO., LTD. |
发明人 |
KIM, JE HAK;LEE, JOON KWANG;SUN, YONG HO;LEE, SEONG GUK;NAM, EUN HYE |
分类号 |
C07C209/88;A61K31/13;A61P25/24;C07C211/42 |
主分类号 |
C07C209/88 |
代理机构 |
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