发明名称 Crystalline forms of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile and methods of preparing the same
摘要 This invention is directed to a crystalline 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile monohydrate having an x-ray diffraction pattern wherein 2theta angles (°) of significant peaks are at about: 9.19, 11.48, 14.32, 19.16, 19.45, 20.46, 21.29, 22.33, 23.96, 24.95, 25.29, 25.84, 26.55, 27.61, and 29.51, and a transition temperature of about 109° C. to about 115° C.
申请公布号 US8445496(B2) 申请公布日期 2013.05.21
申请号 US20100820306 申请日期 2010.06.22
申请人 TESCONI MARC SADLER;FEIGELSON GREGG;STRONG HENRY;WEN HONG;WYETH LLC 发明人 TESCONI MARC SADLER;FEIGELSON GREGG;STRONG HENRY;WEN HONG
分类号 A61K31/497;C07D401/00 主分类号 A61K31/497
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