发明名称 |
Probiotic strain and antimicrobial peptide derived therefrom |
摘要 |
A strain of Enterococcus mundtii has probiotic qualities. The strain of E. mundtii (ST4SA) produces an antimicrobial peptide which exhibits antimicrobial activity against a broad range of bacteria. An isolated nucleotide sequence codes for the antimicrobial peptide (peptide ST4SA). A process is also provided for the production of a peptide which comprises cultivating Enterococcus mundtii strain ST4SA in a nutrient medium under micro-aerophilic conditions at a temperature of between 10° C. and 45° C., until a recoverable quantity of the peptide is produced, and recovering the peptide. The isolated peptide may be used as an antimicrobial agent in a liquid formulation or a gel formulation as a topical treatment and may also be used as an antimicrobial agent following encapsulation in a polymer.
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申请公布号 |
US8444998(B2) |
申请公布日期 |
2013.05.21 |
申请号 |
US201113094155 |
申请日期 |
2011.04.26 |
申请人 |
DICKS LEON MILNER THEODORE;TODOROV SVETOSLAV DIMITROV;KNOETZE HENDRIETTE;BRINK MARELIZE;CIPLA MEDPRO RESEARCH AND DEVELOPMENT (PTY) LTD |
发明人 |
DICKS LEON MILNER THEODORE;TODOROV SVETOSLAV DIMITROV;KNOETZE HENDRIETTE;BRINK MARELIZE |
分类号 |
A61K39/02 |
主分类号 |
A61K39/02 |
代理机构 |
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