发明名称 |
MEDICAL COMPOSITION COMPRISING PERILLA FRUTESCENS EXTRACT FOR PREVENTING OR TREATING BRAIN NEURONAL DISEASE |
摘要 |
PURPOSE: A pharmaceutical composition containing a Perilla frutescens extract or benzo[b]naphtha[2,3-d]thiophene isolated from the extract for preventing or treating neuronal diseases is provided to suppress acetylcholine esterase(AChE), and to effectively prevent, treat, or relieve Alzheimer's disease, dementia, and neurodegenerative diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating neuronal diseases contains a Perilla frutescens extract as an active ingredient. The extract is prepared by using an organic solvent, water, or a mixture thereof. The extract is an ethanol extract. The extract is also an ethyl acetate fraction which is prepared by extracting with ethanol and sequentially fractioning a residue of the Perilla frutescens extract with hexane, chloroform, and ethyl acetate. The extract is a fraction which is prepared by performing silicagel column chromatography using chloroform and ethanol in a ratio of 100:0-80:20. The extract also contains benzo[b]naphtha[2,3-d]thiophene.
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申请公布号 |
KR20130051142(A) |
申请公布日期 |
2013.05.20 |
申请号 |
KR20110116324 |
申请日期 |
2011.11.09 |
申请人 |
KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION |
发明人 |
SHIN, DONG HOON;CHOI, SOO JUNG;KWON, YOON KYUNG;KIM, CHO RONG;CHO, HONG YON;HWANG, HAN JOON;KIM, YOUNG JUN;SUH, SOO HWAN;KIM, HYE KYUNG |
分类号 |
A61K36/535;A61P25/00;A61P25/28 |
主分类号 |
A61K36/535 |
代理机构 |
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