| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: claimed are: synthetic nutritional composition, suitable for application in prevention of secondary infections after viral infection, characterised by neuraminidase activity; said composition contains sialylated oligosaccharide, selected from group, consisting of 3' cilalyllactose, 6' cilalyllactose and their combination and component, selected from group, consisting of N-acetyllactosamine, N-acetyllactosamine-containing oligosaccharide and their combination and its application for obtaining medication or therapeutic nutritional composition for prevention of secondary infection after viral infection, characterised by neuraminidase activity. It is shown that efficiency of viral neuraminidases can be reduced by introduction of excessive sialylated oligosaccharides thus reducing part of decialirated surfaces of epithelial cells until neutral oligisaccarides, which imitate preferable epithelial sites of binding pathogenic bacteria, are supplied in plewnty.EFFECT: combined introduction of sialylated oligosaccharides and N-acetyllactosamine and/or N-acetyllactosamine-containing oligosaccharide is especially efficient in prevention secondary viral infections (otitis media) after such infection as influenza as a result of destruction of synergy between action of viral and bacterial pathogens.13 cl, 1 tbl, 1 ex |
