YEAST HOST, TRANSFORMANT AND METHOD FOR PRODUCING HETEROLOGOUS PROTEINS

摘要

A method of constructing a host for expression of an exogenous gene which comprises deleting or inactivating at least one gene selected from the protease-associated genes of Schizosaccharomyces pombe such as psp3 (SPAC1006.01), sxa2 (SPAC1296.03c), ppp51 (SPAC22G7.01c) or ppp52 (SPBC18A7.01). An isolated or purified host cell in which a protease-associated gene is deleted or inactivated, a transformant obtained by introducing an exogenous gene into the host cell and a method of producing an exogenous or heterologous protein using the transformant.