发明名称 |
TREATMENT MODALITIES TO PREVENT OR TREAT LOSS OF CARDIOVASCULAR FUNCTION IN AGING HUMANS |
摘要 |
Provided herein are methods for treating, preventing or reducing age related vascular stiffness and impaired cardiovascular function in a subject comprising administering to the subject a therapeutic amount of IL-10 or an IL-10 agonist or pharmaceutical compositions comprising the same. Also included herein are methods for determining whether a biologically active agent can treat, prevent or reduce age related vascular stiffness and impaired cardiovascular function using an in vitro model in a IL-10 knockout IL-10(tm/tm) mouse which lacks IL-10 function.
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申请公布号 |
US2013121961(A1) |
申请公布日期 |
2013.05.16 |
申请号 |
US201213674197 |
申请日期 |
2012.11.12 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
SIKKA GAUTAM;BERKOWITZ DAN E.;BAROUCH LILI AYALA;WALSTON JEREMY D. |
分类号 |
C12Q1/02 |
主分类号 |
C12Q1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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