发明名称 |
APTAMER-LOADED, BIOCOMPATIBLE NANOCONSTRUCTS FOR NUCLEAR-TARGETED CANCER THERAPY |
摘要 |
Disclosed herein is a nanoconstruct comprising an aptamer and a gold nanostar. The nanoconstruct can be used in a method of inducing changes to a nuclear phenotype of a cell comprising transporting the nanoconstruct to a nucleus of a cell, and releasing the aptamer from a surface of the gold nanostar into the nucleus of the cell to afford deformations or invaginations in the nuclear membrane, thereby inducing changes to the nuclear phenotype. The method can be used to treat certain hyperproliferative disorders such as cancer. |
申请公布号 |
WO2013070763(A1) |
申请公布日期 |
2013.05.16 |
申请号 |
WO2012US63938 |
申请日期 |
2012.11.07 |
申请人 |
NORTHWESTERN UNIVERSITY |
发明人 |
ODOM, TERI, W.;DAM, DUNCAN-HIEU, M.;LEE, JUNG, HEON |
分类号 |
C12Q1/68;A61K31/7088;A61K48/00;C12N15/115 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|