发明名称 LIPID MEMBRANE STRUCTURE HAVING INTRANUCLEAR MIGRATING PROPERTY
摘要 A lipid membrane structure for delivering a substance into a nucleus of a cell, wherein lipid membrane is modified with (a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, and/or (b) a polypeptide consisting of an amino acid sequence comprising the amino acid sequence of SEQ ID NO: 1, but including deletion and/or substitution and/or insertion of one or several amino acid residues, and having an activity of promoting migration of the lipid membrane structure into a nucleus of a cell, which can efficiently deliver a nucleic acid into a nucleus of an immunocyte such as dendritic cell.
申请公布号 US2013122054(A1) 申请公布日期 2013.05.16
申请号 US201113641812 申请日期 2011.04.20
申请人 HARASHIMA HIDEYOSHI;AKITA HIDETAKA;SHARIF MOHAMMAD SHAHEEN;NAKAMURA TAKASHI;ISHII SOICHIRO;FUTAKI SHIROH;NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY 发明人 HARASHIMA HIDEYOSHI;AKITA HIDETAKA;SHARIF MOHAMMAD SHAHEEN;NAKAMURA TAKASHI;ISHII SOICHIRO;FUTAKI SHIROH
分类号 A61K47/42 主分类号 A61K47/42
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