发明名称 |
COMPOUNDS FOR THE MODULATION OF BETA-CATENIN EXPRESSION AND USES THEREOF |
摘要 |
<p>The invention relates to oligomer compounds (oligomers), which target beta-catenin mRNA in a cell, leading to reduced expression of beta-catenin. Reduction of beta-catenin expression is beneficial for a range of medical disorders, such as hyperproliferative disorders, such as cancers. The invention provides therapeutic compositions comprising oligomers and methods for modulating the expression of beta-catenin using said oligomers, including methods of treatment for hyperproliferative disorders including cancers such as multiple myeloma.</p> |
申请公布号 |
WO2013071161(A1) |
申请公布日期 |
2013.05.16 |
申请号 |
WO2012US64518 |
申请日期 |
2012.11.09 |
申请人 |
ENZON PHARMACEUTICALS, INC.;SANTARIS PHARMA A/S |
发明人 |
DUMBLE, MELISSA;ZHANG, YIXIAN |
分类号 |
C12N15/113;C07H21/04 |
主分类号 |
C12N15/113 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|