| 摘要 |
The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been 5 replaced by a moiety other than ribose. The inclusion of such a monomer can allow for modulation of a property of the iRNA agent into which it is incorporated, e.g., by using the non-ribose moiety as a point to which a ligand or other entity, e.g., a lipophilic moiety, e.g., io cholesterol, is directly, or indirectly tethered. The invention also relates to methods of making and using such modified iRNA agents. 4247584_1 (GHMatters) P58751 .AU.4 11/D4113 WO 2004/IJ94595r 1/Uh9UI w o=P-o. 0 tethering attachment point (R-2) backbone attachmnent points carrer LIGAND RM 0 tether w A: crir R R R7=(-~-- (UIGAND) B: C:me R'O N(R1 2 |
