发明名称 |
DOSAGE FORM, AND METHODS OF MAKING AND USING THE SAME, TO PRODUCE IMMUNIZATION IN ANIMALS AND HUMANS |
摘要 |
An embodiment of the present invention features a dosage form for administering antigen to cause an immune response in an animal or human subject in the nature of a vaccine. The dosage form comprises spheres having an effective amount of antigen to create an immune response and having an average diameter of 0.01 to 10.0 microns. The spheres comprise a polymer selected from the group consisting of poly(L-lactic acid), poly(D, L-lactic acid), poly(glycolic acid) and carboxylic acid and ester derivatives thereof, poly(fumaric anhydride) and poly(sebacic anhydride) and derivatives thereof. The spheres can be lyophilized and stored as a powder prior to use. The spheres can then be reconstituted and formulated in buffers with adjuvants.
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申请公布号 |
US2013122106(A1) |
申请公布日期 |
2013.05.16 |
申请号 |
US201213656175 |
申请日期 |
2012.10.19 |
申请人 |
APHIOS CORPORATION;APHIOS CORPORATION |
发明人 |
CASTOR TREVOR PERCIVAL |
分类号 |
A61K9/19;A61K9/16;A61K39/07 |
主分类号 |
A61K9/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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