COMPOSITIONS AND METHODS FOR INHIBITING THE INTERACTION BETWEEN CFTR AND CAL
摘要
<p>The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.</p>
申请公布号
WO2013070531(A1)
申请公布日期
2013.05.16
申请号
WO2012US63488
申请日期
2012.11.05
申请人
TRUSTEES OF DARTMOUTH COLLEGE;DUKE UNIVERSITY
发明人
MADDEN, DEAN, R.;CUSHING, PATRICK, R.;BOISGUERIN, PRISCA;VOLKMER, RUDOLF;VOUILLEME, LARS;DONALD, BRUCE, R.