发明名称 |
USE OF RANK/RANKL ANTAGONISTS FOR TREATING NEUROMUSCULAR DISORDERS, GENETIC MYOPATHIES AND/OR NON GENETIC MYOPATHIES AND/OR FOR REGULATING SKELETAL AND CARDIAC MUSCLE DISUSE, DISEASES AND AGING |
摘要 |
<p>The present invention relates to uses and methods comprising one or more RANK/RANKL antagonists or of a pharmaceutical composition comprising one or more RANK/RANKL antagonists and a pharmaceutically acceptable carrier for treating neuromuscular disorders, non-genetic myopathies, or genetic myopathies; maintaining and/or preserving the excitation:contraction:relaxation coupling; reducing loss of muscle strenght associated with neuromuscular disorders, non-genetic myopathies or genetic myopathies; reducing the loss of muscular strenght associated with skeletal or cardiac muscle disuse, diseases and aging; or regulating skeletal or cardiac muscle disuse, diseases and/or aging in a patient in need thereof. The present invention also relates to combinations and compositions comprising one or more RANK/RANKL antagonists and to methods for identifying candidate compounds.</p> |
申请公布号 |
WO2013067639(A1) |
申请公布日期 |
2013.05.16 |
申请号 |
WO2012CA50788 |
申请日期 |
2012.11.06 |
申请人 |
UNIVERSITE LAVAL |
发明人 |
FRENETTE, JEROME;PENNINGER, JOSEF |
分类号 |
A61K39/395;A61K31/7105;A61K38/19;A61P21/00;G01N33/48;G01N33/53 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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