发明名称 |
METHOD OF DETERMINING THE PROBABILITY OF A THERAPEUTIC RESPONSE IN CANCER CHEMOTHERAPY WITH CARDIAC GLYCOSIDE |
摘要 |
A method of treatment employing cardiac glycoside is disclosed. A prognostic assay and kit and method of use thereof are provided. The kit and assay are used to determine the likelihood of a diseased cell or tissue having a therapeutic response to treatment with a cardiac glycoside in a disease having an etiology associated with excessive cell proliferation. The kit and assay are used to determine the ratio of isoforms of the α subunit of Na, K-ATPase obtained from the diseased cell or tissue. The kit can be used to predict the therapeutic responsiveness of cancer or tumor in a subject to treatment with a cardiac glycoside. The kit and assay can be incorporated in a method of treating a disease or disorder having an etiology associated with excessive cell proliferation with a composition comprising a cardiac glycoside. |
申请公布号 |
EP2231165(B1) |
申请公布日期 |
2013.05.15 |
申请号 |
EP20080850574 |
申请日期 |
2008.11.06 |
申请人 |
PHOENIX BIOTECHNOLOGY INC. |
发明人 |
NEWMAN, ROBERT, A.;YANG, PEIYING;ADDINGTON, O., CRANDELL |
分类号 |
G01N33/574;A61K31/58;A61K31/704;A61K36/24;G01N33/564 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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