| 摘要 |
THE PRESENT INVENTION CONCERNS THE COMPOUNDS OF FORMULA THE N-OXIDE FORMS, THE PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS AND THE STEREOCHEMICALLY ISOMERIC FORMS THEREOF, WHEREIN Z REPRESENTS NH; Y REPRESENTS -C?-?ALKYL-,-C?-?ALKENYL-,-C?-?ALKYL-CO-NH OPTIONALLY SUBSTITUTED WITH AMINO, MONO- OR DI (C?-?ALKYL)AMINO OR C?-?ALKYLOXYCARBONYLAMINO-,-C?-?ALKENYL-CO-NH-OPTIONALLY SUBSTITUTED WITH AMINO, MONO-OR DI (C?-?ALKYL)AMINO-OR C?-?ALKYLOXYCARBONYLAMINO-,C?-?ALKYL-NR¹³-C?-?ALKYL-,C?-?ALKYL-NR¹?-CO-C?-?ALKYL-,-C?-?ALKYL-CO-NH-,-C?-?ALKYL-NR¹?-C?-?ALKYL-,-C?-?ALKYL-NH-CO-HET²?-,-C?-?ALKYL-CO-HET²¹-CO-,-C?-?ALKYL-NH-CO-CR¹?R¹?-NH-,-C?-?ALKYL-CO-NH-CR¹?R¹?-CO-,-C?-?ALKYL-CO-NR²º-C?-?ALKYL-CO-,OR-NR²²-CO-C?-?ALKYL-NH-; X¹ REPRESENTS A DIREECT BOND, O OR -O-C?-?ALKYL-;X² REPRESENTS A DIRECT BOND,-CO-C?-?ALKYL-,NR¹²,-NR¹²-C?-?ALKYL-,-O-N=CH- OR-C?-?ALKYL-; R¹ AND R² EACH INDEPENDENTLY REPRESENTS HYDROGEN OR HALO;R³ REPRESENTS HYDROGEN;R? REPRESENTS HYDROGEN OR C?-?ALKYLOXY; R¹² AND R¹³ EACH INDEPENDENTLY REPRESENTS HYDROGEN OR C?-?ALKYL; R¹? AND R¹? REPRESENTS HYDROGEN;R¹? AND R¹? EACH INDEPENDENTLY REPRESENT HYDROGEN OR C?-?ALKYL; R¹? AND R¹? EACH INDEPENDENTLY REPRESENT HYDROGEN OR C?-?ALKYL OPTIONALLY SUBSTITUTED WITH PHENYL OR HYDROXY;R²º AND R²¹ EACH INDEPENDENTLY REPRESENT HYDROGEN OR C?-?ALKYL OPTIONALLY SUBSTITUTED WITH C?-?ALKYLOXY;HET²º,HET²¹ AND HET²² EACH INDEPENDENTLY REPRESENT A HETEROCYCLE SELECTED FROM THE GROUP CONSISTING PYRROLIDINYL ,2-PYRROLIDINONYL OR PIPERIDINYL OPTIONALLY SUBSTITUTED WITH HYDROXY. |
