发明名称 |
DETECTION OF MUTATIONS, IN PARTICULAR DELETIONS OR INSERTIONS |
摘要 |
A method for detecting at least one gene modification, such as a mutation in a gene, such as a gene that codes for a protein associated with at least one of a tumor and a cancer. The method includes providing a detectable hybridization probe (sensor probe) which interacts with/binds to a gene not having a gene modification (wild type gene) and with a gene having a gene modification (mutation gene). The detectable hybridization probe (sensor probe) has at least one of a higher specificity, a higher binding affinity and a higher selectivity for the gene not having a gene modification (wild type gene) compared to the gene having a gene modification (mutation gene). At least one gene modification is detected with the detectable hybridization probe (sensor probe). |
申请公布号 |
EP2591124(A1) |
申请公布日期 |
2013.05.15 |
申请号 |
EP20110734008 |
申请日期 |
2011.07.04 |
申请人 |
UNIVERSITAET DUISBURG-ESSEN |
发明人 |
SCHULER, MARTIN;BREITENBUECHER, FRANK;HOFFARTH, SANDRA;STERGAR, SARAH-LUISE |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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